With NBC down and CBS slipping, ABC is taking solid aim at Thursday night, where it has long struggled.

This morning the network confirmed during its upfront schedule announcement that “Grey’s Anatomy” was, as widely speculated, moving. But instead of jumping to Monday, as media people expected, the hit drama is moving to Thursday at 9 p.m., opposite CBS’s “CSI” and NBC’s highly touted new drama “Studio 60 on the Sunset Strip.”

“Grey’s” will anchor ABC’s most aggressive Thursday slate in years, with three new shows launching on the night and longtime 10 p.m. stalwart “Primetime” gone. At 8 p.m., wedding sitcom “Big Day” leads off, with pregnancy comedy “Notes from the Underbelly” at 8:30.

“Grey’s” leads into the drama “Six Degrees,” produced by “Lost’s” J.J. Abrams, about a group of people whose lives intersect by chance.

ABC showed earlier this season that it could program successfully on Thursday, with “Dancing With the Stars” becoming its first Thursday hit in years. Now the network seems determined to get a bigger piece of the most lucrative night of the week.

“There’s certainly not a better show on television [than "Grey’s"]. We feel that it’s a show that deserves a 9 o’clock time period. Thursday is such a classic time for it. There’s a lot of big shows going against each other, and we think there’s room for them all,” ABC entertainment president Steve McPherson said, noting that “Lost” and “American Idol” had proven that two hits can co-exist in the same timeslot.

ABC’s new schedule focuses on Thursday to the detriment of Monday, which stays the same as this spring with “Wife Swap,” “Supernanny” and “What About Brian.” The trio earned the network a consistent fourth place on the night.

ABC will introduce six new dramas and six comedies, as well as three reality series.

Tuesday features the return of “Dancing With the Stars” at 8 p.m., followed by the comedy “Let’s Rob…” and “Help Me Help You,” both new. “Boston Legal” remains at 10.

On Wednesday, the “Stars” results show airs at 8, followed by “According to Jim” at 8:30 and “Lost” at 9 p.m. “The Nine,” a drama about bank robbery victims, airs at 10.

McPherson said “Lost” will air its season in two chunks, one with seven episodes in fall and then an extended run from late January through the end of the season, meaning no repeats. New Taye Diggs drama “Daybreak” will air in the 9 p.m. slot while it’s gone.

The telenovela remake “Betty the Ugly” airs Friday at 8 p.m., followed by Anne Heche drama “Men in Trees” and “20/20” at 10.

Saturdays will be “Saturday Night College Football.”

On Sunday, the first three hours remain the same, with “America’s Funniest Home Videos,” “Extreme Makeover: Home Edition” and “Desperate Housewives.” The Calista Flockhart drama “Brothers & Sisters” gets the coveted post-“Housewives” slot.

None of ABC’s new shows from this season made the schedule, with “Freddie,” “Commander in Chief” and “Invasion” all gone.

“George Lopez” will return at midseason in the Wednesday 8 p.m. slot.

Also set for midseason: new drama “Traveler,” comedy “In Case of Emergency” and reality shows “Greg Behrendt’s Wakeup Call” and “Set for the Rest of Your Life.”