ABC made the most-buzzed-about move of the upfront last year, when it moved hit drama “Grey’s Anatomy” to Thursday night. It may have another one tomorrow, when the network gives its upfront presentation.

There’s been tons of speculation over where the “Grey’s” spinoff, rumored to be titled “Private Practice,” will end up on the schedule. Not only will it be the rare new show that can anchor a night, but it might prompt defensive scheduling from the other networks, which may want to move their most promising new shows out of its way.

As of Friday, media people agreed that “Practice” will most likely air at 8 or 9 p.m. Wednesday, a night where ABC has struggled since “Dancing with the Stars” ended last fall.

After seeing its adults 18-49 audience plunge 13 percent this year without the Super Bowl or “Monday Night Football,” ABC has a lot of trouble spots on its schedule. It is expected to pick up 10 new shows tomorrow, including seven dramas, and make changes to every night of the week.

“Practice” is a sure thing to make the schedule after earning solid ratings as part of a two-hour “Grey’s” two weeks ago.

“[ABC] has so many holes to fill, and this would have a built-in audience,” says John Spiropoulos, MediaVest’s vice president and group research director, video investment and activation. “We’re expecting it to anchor Wednesday with ‘Lost’ off the air till January.”

He says it could be paired with “Brothers & Sisters,” the first-year show that performed solidly behind “Desperate Housewives” this year, opening the Sunday 10 p.m. slot for a new drama.

The other place “Practice” could land, say media people, is behind “Grey’s” on Thursday at 10 p.m., ensuring the network would dominate the final two hours of primetime on the week’s most lucrative night. But the network seems more likely to use that valuable slot to launch a new show.

ABC has already renewed many of its shows, including “Lost,” which will air without reruns starting in January or February. First-year show “Men in Trees” will return, probably on Monday or Friday, and “Ugly Betty” will also be back. Though one rumor has “Betty” moving to Monday, it will likely stay on Thursdays.

“What we’re looking to see from the networks is how are they going to tweak their lineups to offer new shows the best possible launch,” Spiropoulos says. “They used to have new shows lead off nights, but that’s always a tough proposition for a show that doesn’t have a built-in audience.”

“Stars” likely will air Monday and Tuesday through November, with a half hour comedy leading out of the Tuesday show. That could be “Knights of Prosperity,” the first-year sitcom that was yanked months ago but remains well-liked by the network. ABC will give the show another chance with “Everybody Loves Raymond’s” Ray Romano replacing Mick Jagger as the celebrity target this time.

Another first-year sitcom, “Notes from the Underbelly,” is expected to return after “Stars” ends, but “George Lopez” will be canceled after six seasons. "According to Jim" may return.

Among the drama pilots getting picked up are “Pushing Daisies,” about a man who can bring people back to life; “Big Shots,” about a group of male friends; James Patterson's “Women's Murder Club;” “Dirty Sexy Money,” about a man who inherits his late father’s crooked law firm; and “Cashmere Mafia,” from “Sex and the City” executive producer Darren Star. "Footballers Wives," the buzzed-about BBC adaptation, apparently fell out of favor recently and is not expected to be picked up, but "Miss/Guided" may be.

New comedies will include Christina Applegate’s “Sam I Am” and “Cavemen,” based on the Geico commercials, as well as "Carpoolers."

Bubble show “October Road” will likely return at midseason, but “What About Brian” is dead.